Professor Enrico Dall'Ara
PhD
Clinical Medicine, School of Medicine and Population Health
Professor of Musculoskeletal Biomechanics
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e.dallara@sheffield.ac.uk
+44 114 222 6175
+44 114 222 6175
C+31, Pam Liversidge Building; DU19, The Medical School
Full contact details
Professor Enrico Dall'Ara
Clinical Medicine, School of Medicine and Population Health
C+31, Pam Liversidge Building; DU19
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
C+31, Pam Liversidge Building; DU19
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I have been Full Professor of Musculoskeletal Biomechanics since 2024.
I hold a PhD from the Vienna University of Biomechanics and a Master in Mechanical Engineering from the University of Bologna.
I am the Director of the Skelet.Al laboratories, the Research Director of the Insigneo Computational Modelling in Medicine research theme, and the Head of the Integrative MusculoSkeletal Biomechanics (IMSB) Research group.
I am the Secretary general of the European Society of Biomechanics and the President of the UK Chapter of the Virtual Physiological Human institute.
I co-lead the Non-Clinical task force of the Avicenna Alliance.
Current PhD Opportunities:
- Research interests
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My research interests are related to better understanding the properties of musculoskeletal tissues across the space and time scales, by using imaging, experimental and computational methods. In particular, the main goal of my research is to develop and validate subject-specific computational models for the prediction of bone strength, bone remodelling and risk of fracture in healthy subjects and in patients with musculoskeletal diseases, applied to both preclinical and clinical studies.
Research projects:
- Validation of Finite Element models for bone at different dimensional levels
- Development and validation of multiscale models for predicting bone remodelling over time
- Preclinical assessment of osteoarthritis with longitudinal microCT
- Development of Finite Element models to study the outcomes of spine fixation
- Prediction of fracture risk for patients with vertebral metastases with QCT based computational models
- Investigation of the effect of bone metastatic lesions on bone strength
- Investigation of the mechanical properties of subchondral bone from OA patients
- Optimisation of Digital Volume Correlation techniques for measuring deformation in heterogeneous biomaterials
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
- The role of bone metastases on the mechanical competence of human vertebrae. Bone, 173, 116814-116814.
- Prediction of the 3D shape of the L1 vertebral body from adjacent vertebrae. Medical Image Analysis, 87, 102827-102827.
- Deformable image registration based on single or multi-atlas methods for automatic muscle segmentation and the generation of augmented imaging datasets. PLoS ONE, 18(3).
- Accuracy of in vivo microCT imaging in assessing the microstructural properties of the mouse tibia subchondral bone. Frontiers in Endocrinology, 13.
- Reproducibility of densitometric and biomechanical assessment of the mouse tibia from in vivo micro-CT images. Frontiers in Endocrinology, 13. View this article in WRRO
- A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography. Journal of the Mechanical Behavior of Biomedical Materials, 133. View this article in WRRO
- Geroprotectors and skeletal health : beyond the headlines. Frontiers in Cell and Developmental Biology, 10. View this article in WRRO
- MicroFE models of porcine vertebrae with induced bone focal lesions : validation of predicted displacements with digital volume correlation. Journal of the Mechanical Behavior of Biomedical Materials, 125. View this article in WRRO
- Type, size, and position of metastatic lesions explain the deformation of the vertebrae under complex loading conditions. Bone, 151. View this article in WRRO
- Positive interactions of mechanical loading and PTH treatments on spatio-temporal bone remodelling.. Acta Biomater. View this article in WRRO
- Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: building model credibility. CPT: Pharmacometrics & Systems Pharmacology. View this article in WRRO
- Damage tolerance and toughness of elderly human femora. Acta Biomaterialia, 123, 167-177. View this article in WRRO
- Patient-specific finite element models of posterior pedicle screw fixation : effect of screw’s size and geometry. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
- Non-invasive prediction of the mouse tibia mechanical properties from microCT images: comparison between different finite element models. Biomechanics and Modeling in Mechanobiology. View this article in WRRO
- A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint. Scientific Reports, 10(1). View this article in WRRO
- Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications. Journal of the Mechanical Behavior of Biomedical Materials. View this article in WRRO
- Heterogeneous strain distribution in the subchondral bone of human osteoarthritic femoral heads, measured with digital volume correlation. Materials, 13(20). View this article in WRRO
- Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: A combined in vivo/in silico study. Acta Biomaterialia.
- PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse. Scientific Reports, 10(1). View this article in WRRO
- Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models. Journal of the Mechanical Behavior of Biomedical Materials, 98, 268-290. View this article in WRRO
- The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia : a comparison between two mouse strains. Bone, 127, 260-270. View this article in WRRO
All publications
Journal articles
- Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
- Cortical thickness adaptation to combined mechanical loading and parathyroid hormone treatments is site specific and synergistic in the mouse tibia model. Bone, 180, 116994-116994.
- The role of bone metastases on the mechanical competence of human vertebrae. Bone, 173, 116814-116814.
- Prediction of the 3D shape of the L1 vertebral body from adjacent vertebrae. Medical Image Analysis, 87, 102827-102827.
- Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm. Frontiers in Bioengineering and Biotechnology, 11.
- Deformable image registration based on single or multi-atlas methods for automatic muscle segmentation and the generation of augmented imaging datasets. PLoS ONE, 18(3).
- Accuracy of in vivo microCT imaging in assessing the microstructural properties of the mouse tibia subchondral bone. Frontiers in Endocrinology, 13.
- Comparison of linear and nonlinear stepwise μFE displacement predictions to digital volume correlation measurements of trabecular bone biopsies. Journal of the Mechanical Behavior of Biomedical Materials, 138.
- Effect of radiation-induced damage of trabecular bone tissue evaluated using indentation and digital volume correlation. Journal of the Mechanical Behavior of Biomedical Materials, 138.
- Editorial: Computational modeling for the assessment of the biomechanical properties of the healthy, diseased and treated spine. Frontiers in Bioengineering and Biotechnology, 10.
- Digital volume correlation for the characterization of musculoskeletal tissues: current challenges and future developments. Frontiers in Bioengineering and Biotechnology, 10.
- Reproducibility of densitometric and biomechanical assessment of the mouse tibia from in vivo micro-CT images. Frontiers in Endocrinology, 13. View this article in WRRO
- A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography. Journal of the Mechanical Behavior of Biomedical Materials, 133. View this article in WRRO
- Geroprotectors and skeletal health : beyond the headlines. Frontiers in Cell and Developmental Biology, 10. View this article in WRRO
- MicroFE models of porcine vertebrae with induced bone focal lesions : validation of predicted displacements with digital volume correlation. Journal of the Mechanical Behavior of Biomedical Materials, 125. View this article in WRRO
- High bone mass phenotype in a cohort of patients with Osteogenesis Imperfecta caused due to BMP1 and C-propeptide cleavage variants in COL1A1. Bone Reports, 15.
- Subchondral bone microarchitectural and mineral properties and expression of key degradative proteinases by chondrocytes in human hip osteoarthritis. Biomedicines, 9(11).
- Type, size, and position of metastatic lesions explain the deformation of the vertebrae under complex loading conditions. Bone, 151. View this article in WRRO
- Positive interactions of mechanical loading and PTH treatments on spatio-temporal bone remodelling.. Acta Biomater. View this article in WRRO
- The role of the loading condition in predictions of bone adaptation in a mouse tibial loading model. Frontiers in Bioengineering and Biotechnology, 9.
- Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: building model credibility. CPT: Pharmacometrics & Systems Pharmacology. View this article in WRRO
- A novel approach to evaluate the effects of artificial bone focal lesion on the three-dimensional strain distributions within the vertebral body. PLoS ONE, 16(6).
- Subchondral bone microarchitecture and mineral density in human osteoarthritis and osteoporosis : a regional and compartmental analysis. Journal of Orthopaedic Research.
- Damage tolerance and toughness of elderly human femora. Acta Biomaterialia, 123, 167-177. View this article in WRRO
- Patient-specific finite element models of posterior pedicle screw fixation : effect of screw’s size and geometry. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
- Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden information within the signalling noise. Interface Focus, 11(1). View this article in WRRO
- Non-invasive prediction of the mouse tibia mechanical properties from microCT images: comparison between different finite element models. Biomechanics and Modeling in Mechanobiology. View this article in WRRO
- Correlation between the mechanical properties of the metastatic vertebrae and the features of the lesions. Brain and Spine, 1, 100047-100047.
- Oral Communications & Poster Abstracts. JBMR PLUS, 5.
- A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint. Scientific Reports, 10(1). View this article in WRRO
- Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications. Journal of the Mechanical Behavior of Biomedical Materials. View this article in WRRO
- Full-field comparisons between strains predicted by QCT-derived finite element models of the scapula and experimental strains measured by digital volume correlation. Journal of Biomechanics. View this article in WRRO
- Heterogeneous strain distribution in the subchondral bone of human osteoarthritic femoral heads, measured with digital volume correlation. Materials, 13(20). View this article in WRRO
- Development of subject specific finite element models of the mouse knee joint for preclinical applications. Frontiers in Bioengineering and Biotechnology, 8. View this article in WRRO
- Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: A combined in vivo/in silico study. Acta Biomaterialia.
- The Application of Digital Volume Correlation (DVC) to Evaluate Strain Predictions Generated by Finite Element Models of the Osteoarthritic Humeral Head. Annals of Biomedical Engineering, 48(12), 2859-2869. View this article in WRRO
- PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse. Scientific Reports, 10(1). View this article in WRRO
- A novel algorithm to predict bone changes in the mouse tibia properties under physiological conditions.. Biomechanics and modeling in mechanobiology, 19(3), 985-1001.
- Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study. Bone Reports, 12, 100257-100257.
- Revealing hidden information in osteoblast’s mechanotransduction through analysis of time patterns of critical events. BMC Bioinformatics, 21(1). View this article in WRRO
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia. PLoS ONE, 14(11).
- Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models. Journal of the Mechanical Behavior of Biomedical Materials, 98, 268-290. View this article in WRRO
- The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia : a comparison between two mouse strains. Bone, 127, 260-270. View this article in WRRO
- Performance of QCT-Derived scapula finite element models in predicting local displacements using digital volume correlation. Journal of the Mechanical Behavior of Biomedical Materials, 97, 339-345. View this article in WRRO
- A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones. PLoS ONE, 14(7). View this article in WRRO
- Material mapping of QCT-derived scapular models : a comparison with micro-CT loaded specimens using digital volume correlation. Annals of Biomedical Engineering. View this article in WRRO
- Full-field strain analysis of bone-biomaterial systems produced by the implantation of osteoregenerative biomaterials in an ovine model. ACS Biomaterials Science & Engineering. View this article in WRRO
- Uncertainties of synchrotron microCT-based digital volume correlation bone strain measurements under simulated deformation.. J Biomech, 86, 232-237. View this article in WRRO
- Prenatal growth map of the mouse knee joint by means of deformable registration technique.. PLoS One, 14(1), e0197947. View this article in WRRO
- From bed to bench: How in silico medicine can help ageing research.. Mech Ageing Dev, 177, 103-108.
- Variability in strain distribution in the mice tibia loading model: A preliminary study using digital volume correlation.. Med Eng Phys, 62, 7-16. View this article in WRRO
- Effect of SR-microCT radiation on the mechanical integrity of trabecular bone using in situ mechanical testing and digital volume correlation.. J Mech Behav Biomed Mater, 88, 109-119. View this article in WRRO
- Comparison of HR-pQCT- and microCT-based finite element models for the estimation of the mechanical properties of the calcaneus trabecular bone.. Biomech Model Mechanobiol, 17(6), 1715-1730. View this article in WRRO
- Preservation of Bone Tissue Integrity with Temperature Control for In Situ SR-MicroCT Experiments.. Materials (Basel), 11(11). View this article in WRRO
- Validation of finite element models of the mouse tibia using digital volume correlation.. J Mech Behav Biomed Mater, 86, 172-184.
- Mapping anisotropy improves QCT-based finite element estimation of hip strength in pooled stance and side-fall load configurations.. Med Eng Phys, 59, 36-42. View this article in WRRO
- Comparison of femoral strength and fracture risk index derived from DXA-based finite element analysis for stratifying hip fracture risk: A cross-sectional study.. Bone, 110, 386-391.
- Validation of calcaneus trabecular microstructure measurements by HR-pQCT.. Bone, 106, 69-77. View this article in WRRO
- Precision of Digital Volume correlation approaches for strain analysis in Bone imaged with Micro-computed Tomography at Different Dimensional levels. FRONTIERS IN MATERIALS, 4.
- Effect of integration time on the morphometric, densitometric and mechanical properties of the mouse tibia.. J Biomech, 65, 203-211. View this article in WRRO
- Longitudinal effects of Parathyroid Hormone treatment on morphological, densitometric and mechanical properties of mouse tibia.. J Mech Behav Biomed Mater, 75, 244-251. View this article in WRRO
- Micro Finite Element models of the vertebral body: Validation of local displacement predictions.. PLoS One, 12(7), e0180151.
- Local displacement and strain uncertainties in different bone types by digital volume correlation of synchrotron microtomograms.. J Biomech, 58, 27-36. View this article in WRRO
- Strain uncertainties from two digital volume correlation approaches in prophylactically augmented vertebrae: Local analysis on bone and cement-bone microstructures.. J Mech Behav Biomed Mater, 67, 117-126. View this article in WRRO
- Micro-CT based finite element models of cancellous bone predict accurately displacement once the boundary condition is well replicated: A validation study.. J Mech Behav Biomed Mater, 65, 644-651. View this article in WRRO
- Digital volume correlation can be used to estimate local strains in natural and augmented vertebrae: An organ-level study.. J Biomech, 49(16), 3882-3890. View this article in WRRO
- Experimental validation of DXA-based finite element models for prediction of femoral strength.. J Mech Behav Biomed Mater, 63, 17-25. View this article in WRRO
- Rotational stability in screw-fixed scaphoid fractures compared to plate-fixed scaphoid fractures.. Arch Orthop Trauma Surg, 136(11), 1623-1628.
- Longitudinal imaging of the ageing mouse.. Mech Ageing Dev, 160, 93-116. View this article in WRRO
- Development of a protocol to quantify local bone adaptation over space and time: Quantification of reproducibility.. J Biomech, 49(10), 2095-2099. View this article in WRRO
- The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength.. J Bone Miner Res, 31(2), 341-346. View this article in WRRO
- Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation.. J Biomech, 48(15), 4073-4080. View this article in WRRO
- Evaluation of in-vivo measurement errors associated with micro-computed tomography scans by means of the bone surface distance approach.. Med Eng Phys, 37(11), 1091-1097. View this article in WRRO
- Three-Dimensional Local Measurements of Bone Strain and Displacement: Comparison of Three Digital Volume Correlation Approaches. Journal of Biomechanical Engineering, 137(7). View this article in WRRO
- About the inevitable compromise between spatial resolution and accuracy of strain measurement for bone tissue: a 3D zero-strain study.. Journal of biomechanics, 47(12), 2956-2963.
- Orthotropic HR-pQCT-based FE models improve strength predictions for stance but not for side-way fall loading compared to isotropic QCT-based FE models of human femurs. Journal of the Mechanical Behavior of Biomedical Materials, 32, 287-299.
- Assessment of transverse isotropy in clinical-level CT images of trabecular bone using the gradient structure tensor.. Ann Biomed Eng, 42(5), 950-959.
- Clinical versus pre-clinical FE models for vertebral body strength predictions.. J Mech Behav Biomed Mater, 33, 76-83.
- Tissue properties of the human vertebral body sub-structures evaluated by means of microindentation.. J Mech Behav Biomed Mater, 25, 23-32.
- Finite element analysis for prediction of bone strength.. Bonekey Rep, 2, 386.
- Calcium phosphate cement augmentation after volar locking plating of distal radius fracture significantly increases stability. European Journal of Orthopaedic Surgery and Traumatology, 1-7.
- DXA predictions of human femoral mechanical properties depend on the load configuration.. Med Eng Phys, 35(11), 1564-1572.
- A nonlinear QCT-based finite element model validation study for the human femur tested in two configurations in vitro.. Bone, 52(1), 27-38.
- Removal of the cortical endplates has little effect on ultimate load and damage distribution in QCT-based voxel models of human lumbar vertebrae under axial compression.. J Biomech, 45(9), 1733-1738.
- Microindentation can discriminate between damaged and intact human bone tissue.. Bone, 50(4), 925-929.
- QCT-based finite element models predict human vertebral strength in vitro significantly better than simulated DEXA.. Osteoporos Int, 23(2), 563-572.
- HR-pQCT-based homogenised finite element models provide quantitative predictions of experimental vertebral body stiffness and strength with the same accuracy as μFE models.. Comput Methods Biomech Biomed Engin, 15(7), 711-720.
- Assessment of a novel biomechanical fracture model for distal radius fractures.. BMC Musculoskelet Disord, 13, 252.
- OPG-Fc treatment in growing pigs leads to rapid reductions in bone resorption markers, serum calcium, and bone formation markers.. Horm Metab Res, 43(13), 944-949.
- Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral.. Bone, 49(6), 1232-1241.
- Validation of an HR-pQCT-based homogenized finite element approach using mechanical testing of ultra-distal radius sections.. Biomech Model Mechanobiol, 10(4), 431-444.
- Bone and cellular immune system of multiparous sows are insensitive to ovariectomy and nutritive calcium shortage.. Horm Metab Res, 43(6), 404-409.
- Reduced tissue hardness of trabecular bone is associated with severe osteoarthritis.. J Biomech, 44(8), 1593-1598.
- A calibration methodology of QCT BMD for human vertebral body with registered micro-CT images.. Med Phys, 38(5), 2602-2608.
- Multidirectional volar fixed-angle plating using cancellous locking screws for distal radius fractures--evaluation of three screw configurations in an extra-articular fracture model.. Wien Klin Wochenschr, 123(1-2), 4-10.
- Volar fixed-angle plating of extra-articular distal radius fractures--a biomechanical analysis comparing threaded screws and smooth pegs.. J Trauma, 69(5), E46-E55.
- A nonlinear finite element model validation study based on a novel experimental technique for inducing anterior wedge-shape fractures in human vertebral bodies in vitro.. J Biomech, 43(12), 2374-2380.
- Research Network Osteology Vienna (RNO): High-resolution and micro-computed tomography in viennese osteological research. Journal fur Mineralstoffwechsel, 17(3), 104-109.
- The effects of embalming using a 4% formalin solution on the compressive mechanical properties of human cortical bone.. Clin Biomech (Bristol, Avon), 23(10), 1294-1298.
- An accurate estimation of bone density improves the accuracy of subject-specific finite element models.. J Biomech, 41(11), 2483-2491.
- Mechanical testing of cancellous bone from the femoral head: experimental errors due to off-axis measurements.. J Biomech, 40(11), 2426-2433.
- The effect of tissue condition and applied load on Vickers hardness of human trabecular bone.. J Biomech, 40(14), 3267-3270.
- Cortical bone adaptation response is region specific, but not peak load dependent: insights from $$mu$$CT image analysis and mechanostat simulations of the mouse tibia loading model. Biomechanics and Modeling in Mechanobiology.
- Regional Nanoindentation Properties in Different Locations on the Mouse Tibia From C57BL/6 and Balb/C Female Mice. Frontiers in Bioengineering and Biotechnology, 8. View this article in WRRO
- ChronoMID—Cross-modal neural networks for 3-D temporal medical imaging data. PLOS ONE, 15(2), e0228962-e0228962. View this article in WRRO
- Damage Tolerance and Toughness of Elderly Human Femora. SSRN Electronic Journal.
- The Digital Mouse: why computational modelling of mouse models of disease can improve translation.
Chapters
- Bone strength, bone remodeling, and Biomechanics of fracture, Digital Human Modeling and Medicine (pp. 515-546). Elsevier
- Bone biomechanics, Human Orthopaedic Biomechanics (pp. 97-120). Elsevier
- Analysis of Bone Architecture in Rodents Using Micro-Computed Tomography, Methods in Molecular Biology (pp. 507-531). Springer New York
- Advanced Techniques of Bone Mass Measurements and Strength in Adults (pp. 260-271). Wiley
Conference proceedings papers
- SPATIAL VARIATIONS OF BONE MICROARCHITECTURE AND MINERALIZATION IN HIP OSTEOARTHRITIS AND OSTEOPOROSIS. ANNALS OF THE RHEUMATIC DISEASES, Vol. 79 (pp 1334-1334)
- Regional and compartmentalized variation of subchondral bone mineralization and microarchitecture in hip osteoarthritis. Osteoarthritis and Cartilage, Vol. 28 (pp S174-S174)
- Longitudinal Effects of Combined Bone Anabolic Interventions on Ovariectomised Mice. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 258-259)
- HOW DOES THE INITIAL SLOPE OF THE VARIOGRAM, THE TEXTURAL BASIS OF THE TRABECULAR BONE SCORE, PREDICT VERTEBRAL STRENGTH?. OSTEOPOROSIS INTERNATIONAL, Vol. 27 (pp S105-S105)
- Femoral strength computed from QCT-based finite element analyses is not influenced by voxel or smooth mesh type. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- QCT-BMD TO MICROCT-BV/TV CALIBRATION RELATIONSHIPS ARE SIMILAR FOR HUMAN VERTEBRA AND FEMUR. Journal of Biomechanics, Vol. 45 (pp S450-S450)
- Vertebral strength prediction with an increased QCT resolution: Densitometry versus FEA. Bone, Vol. 48 (pp S176-S176)
- The skeleton of multiparous sows is protected from effects of ovariectomy and calcium deprivation. Bone, Vol. 48 (pp S198-S198)
- Local BMD calibration of human vertebrae QCT using registered Micro-CT images. Bone, Vol. 47 (pp S81-S82)
Reports
- In silico Clinical Trials: How Computer Simulations Will Transform the Biomedical Industry. An International Roadmap for an Industry-Driven Initiative.
Software / Code
- Code used in the study "ChronoMID - cross-modal neural networks for 3-D temporal medical imaging data".
- Code used in the study "A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones".
Datasets
- Data for the paper: "PTH(1-34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse".
- Data for MicroCT-based MicroFE of human vertebrae.
- Data used in the study "Regional Nanoindentation Properties in Different Locations on the Mouse Tibia from C57BL/6 and Balb/C female mice".
- Data used in the study "ChronoMID - cross-modal neural networks for 3-D temporal medical imaging data".
- Data used in the study "Effect of repeated in vivo microCT imaging on the properties of the mouse tibia".
- Data used in the study "A novel algorithm to predict bone changes in the mouse tibia properties under physiological conditions".
- Data used in the study "A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones".
- Data for the paper: "The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: a comparison between two mouse strains".
- Data for the paper: "Uncertainties of Synchrotron microCT-based Digital Volume Correlation bone strain measurements under simulated deformation".
- MicroCT Dataset of mouse tibiae for evaluating the effect of the integration time on output parameters.
- METVERT_Validation_Results: Micro Finite Element models of the vertebral body: Validation of local displacement predictions.
- Dataset SRACC: Synchrotron microCT for testing accuracy of Digital Volume Correlation (DVC) methods.
- Data for the paper: "Development of subject-specific finite element models of the mouse knee joint for preclinical applications".
- Data for the paper: "Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: a combined in vivo/ in silico study".
- Data for the paper: "Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications".
Other
- Corrigendum to "An accurate estimation of bone density improves the accuracy of subject-specific finite element" [J. Biomech. 41 (2008) 2483-2491] (DOI:10.1016/j.jbiomech.2008.05.017). Journal of Biomechanics, 41(15), 3294.
- Data used in the study "Prenatal growth map of the mouse knee joint by means of deformable registration technique".
- MicroCT, DVC and MicroFE datasets for the validation for finite element models of the Mouse Tibia.
- MicroCT Dataset of mouse tibiae for DVC precision analyses (repeated scans ex vivo and in vivo).
Preprints
- Deformable image registration for automatic muscle segmentation and the generation of augmented imaging datasets, Cold Spring Harbor Laboratory.
- Combining PTH(1-34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice, Research Square Platform LLC.
- ABM of osteoblast's mechanotransduction pathway: time patterns of
critical events, arXiv.
- ChronoMID - Cross-Modal Neural Networks for 3-D Temporal Medical Imaging Data, arXiv.
- Prenatal growth map of the mouse knee joint by mean of deformable registration technique, Cold Spring Harbor Laboratory.
- Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
- Research group
-
- Ms Saira Frage-O'Reilly (PhD student, 1st sup.)
- Ms Stamatina Moraiti (PhD student, 2nd sup.)
- Ms Fiona Gibson (PhD student, 2nd sup.)
- Mr Zhicheng Lin (PhD student, 2nd sup.)
- Ms Giulia Cavazzoni (PhD student, UniBo, 3rd sup.)
- Mr Keir Robson (PhD student, 2nd sup.)
- Mr Robert Roger (PhD student, 1st sup.)
- Grants
-
- 2023-2028; Dall’Ara E (UoS PI, WP leader), Lacroix D, et al. [Coordinator UniBo]: “METASTRA: Computer-aided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through robust computational models validated in clinical settings”; EU HorizonEurope; ~6M euro [~£773k to Sheffield]
- 2022-2027; van Lenthe H, Ruffoni D, Dall’Ara E, Stok K; “Understanding joint health: biomechanical and mechanobiological characterization of the bone-cartilage interface (UNITE)”; FNRS and FWO (Belgium, EOS excellence of Science scheme); ~€2000k [€94.5k to Sheffield]
- 2022-2023; Palanca M, Dall’Ara E, Cristofolini L; 2022-2023, “Effect of the IVD conditions on the risk of vertebral fracture in metastatic patients”; AO Spine Knowledge Forum Associate Research Award, €24k
- 2020-2024; Farage-O’Reilly S, Dall’Ara E; “Multi-scale models for the prediction of bone remodelling due to musculoskeletal interventions”: PhD studentships EPSRC; ~£70k
- 2020-2024; Inksson B (PI), Pinna C, Dall'Ara E, Fairclough JPA, Moebus G, Hounslow MJ, Cumming D, Reeves-McLaren N; “An X-ray Micro-Computed Tomography Facility with in-situ/in operando testing”: EPSRC ; £1412k
- 2019-2026; Narracott AJ (PI), Fenner JW, Gunn JP, Clayton RH, Mazza C, Reilly G, Lawford PV, Wild JM, Hose DR, Marzo A, Villa-Uriol MC, Li X, Guo L, Dall'Ara E, Bhattacharya P, Walker DC, Watton P; “Centre for New Methods in Computational Diagnostics and Personalised Therapy (SANO)”: Horizon2020; €2897k
- 2019-2021; Dall’Ara E (PI), Palanca M; “Comprehensive experimental and computational mechanical characterization of metastatic vertebrae (METASPINE)”: Horizon2020, Marie Curie Intra-European Fellowship; €213k
- 2019-2021; Mazza’ C (PI), Dall’Ara E, Li X, Battacharia P, Kadirkamanathan V, McCloskey E; “Frontier Engineering: Progression Grant in Modelling complex and partially identified engineering problems. Application to the musculoskeletal system (MULTISIM2)”: Progression Grant EPSRC; £758k
- 2019-2020; Dall’Ara E (PI); “Equipment for Mouse gait lab”: EPSRC ECR Capital Enhancement Programme 2018
- 2018-2022; Reilly G (PI), Mazza’ C, Lacroix D, Claeyssen F, Guo L, Dall’Ara E; “SPINe: Numerical and Experimental Repair strategies”: Horizon2020 European program, Initial Training Network; £476k
- 2017-2020; Dall’Ara E (PI), Bellantuono I, Viceconti M; “In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies”: National Centre for replacement, refinement and reduction of animal use in research; £353k
- 2017-2019; Bellantuono I (PI), Dall’Ara E; “Targeting mechanisms of ageing to maintain musculoskeletal health”: Biological and Biotechnological Sciences Research Council; £261k
- 2017-2019; Dall’Ara E (PI); “Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation”: Engineering and Physical Sciences Research Council; £101k
- 2015-2016; Dall’Ara E (PI); “Multiscale characterization of osteoarthritic subchondral bone: combination of microCT, elastic registration and microindentation”: Royal Society research grant; £15k
- 2016-2019; Dall’Ara E (PI), Hose R, Lawford P; “Assessment of bone growth in preclinical studies with Kalman filtering”: EPSRC PhD scholarship; £65k
- 2015-2018; Dall’Ara E (PI), Viceconti M; “Prediction of the risk of vertebral fracture in patients with metastatic lesions as a tool for more effective patients’ management”: Sheffield Hospitals Charity; £65k
- 2013-2015; Dall’Ara E (Fellow), Viceconti M; “Methodologically and Accurate modelling of bone”: FP7, Marie Curie Intra-European Fellowship; €222k
- Teaching interests
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I teach in the Computational Biomechanics of the Musculoskeletal System (MEC457, BIE6433).
I give invited lectures in different modules in engineering.
- Professional activities and memberships
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- Director of the SkeletAl laboratory since 2020;
- Research Director Insigneo "Computational Modelling in Medicine" research theme since 2021;
- Head of the Integrative Musculoskeletal Biomechanics (IMSB) group since 2022;
- Member of Mellanby centre for Musculoskeletal Research Exec Committee since 2021;
- Secretary General of the European Society of Biomechanics since 2022;
- Council member for the European Society of Biomechanics since 2018 (Secretary General since 2022);
- President of the UK chapter of the Virtual Physiological Human Institute since 2018;
- Deputy chair of the Working Group 3 of the Bone Metastases Group of the National Cancer Research Institute in 2023;
- Editorial Board member of the Journal of Mechanical Behaviour of Biomedical Materials since 2019;
- Associate Editor for Frontiers in Bioengineering and Biotechnology (Biomechanics) since 2022;
- Member of the ESB since 2008, BRS since 2014, ECTS since 2015 and ORS since 2017;
- Reviewer for the major journals of biomechanics and bone research.