Professor Alison Gartland
BSc (Hons), PhD
Clinical Medicine, School of Medicine and Population Health
Professor of Bone and Cancer Biology
a.gartland@sheffield.ac.uk
+44 114 215 9046
+44 114 215 9046
DU34, The Medical School
Full contact details
Professor Alison Gartland
Clinical Medicine, School of Medicine and Population Health
DU34
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Clinical Medicine, School of Medicine and Population Health
DU34
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk
I studied Biomedical Technology at Sheffield Hallam University and - following a period in industry - studied for my PhD at The University of Liverpool in Prof Jim Gallagher´s lab on the "Expression and functional significance of the P2X7 receptor in skeletal tissue".
I then moved to Montpellier, France where I was a Post-Doctoral Researcher at IGMM, CNRS in Bob Hipskind´s lab. Following this, I was a Senior Post-Doctoral Researcher in the Department of Cell Biology at the University of Massachusetts Medical School USA, in the late Prof Sandy Marks Jnr´s lab.
I joined the University of Sheffield in 2006 as a Lecturer in Bone Biology.
- Research interests
-
My research interests are in P2 receptor signalling in musculoskeletal disease and cancer. The role of P2 purinoreceptor ligands (ATP and other nucleotides) as extracellular messengers is well established and there is now conclusive evidence, from my previous work and that of others, that extracellular nucleotides have a highly influential role in the bone microenvironment. In addition to their roles in bone, nucleotides and P2 receptor signalling have been shown to play a role in cancer.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. Journal of Bone Oncology. View this article in WRRO
- Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing. Frontiers in Endocrinology, 7. View this article in WRRO
- Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. Purinergic Signalling, 12(1), 103-113.
- Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis. Cancer Research, 76(2), 188-192.
- Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data in Brief, 5, 621-625. View this article in WRRO
- The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature, 522(7554), 106-110. View this article in WRRO
- Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
- P2X7 receptors: role in bone cell formation and function. Journal of Molecular Endocrinology, 54(2), R75-R88.
- Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
- The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.. J Bone Miner Res, 28(6), 1446-1456. View this article in WRRO
- Generation of a novel mouse model for the inducible depletion of macrophages in vivo.. Genesis, 51(1), 41-49.
- Genetic background strongly influences the bone phenotype of P2X7 receptor knockout mice. Journal of Osteoporosis, 2012. View this article in WRRO
- Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.. Eur J Hum Genet, 20(5), 559-564. View this article in WRRO
- P2X receptors in bone. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 1(2), 221-227.
- Purinergic signalling in bone.. Front Endocrinol (Lausanne), 3, 116. View this article in WRRO
- Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics.
- Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.. Mol Endocrinol, 26(1), 142-152. View this article in WRRO
- Primary human osteoblast cultures.. Methods Mol Biol, 816, 3-18.
- Purinergic signalling in osteoblasts.. Front Biosci (Landmark Ed), 17, 16-29.
- Human osteoclast culture and phenotypic characterization.. Methods Mol Biol, 806, 357-375.
- Isolation and culture of human osteoblasts.. Methods Mol Biol, 806, 337-355.
- Application of multiple forms of mechanical loading to human osteoblasts reveals increased ATP release in response to fluid flow in 3D cultures and differential regulation of immediate early genes.. J Biomech, 45(3), 549-554.
- The P2Y(6) receptor stimulates bone resorption by osteoclasts.. Endocrinology, 152(10), 3706-3716. View this article in WRRO
- Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.. Bone, 49(4), 717-723. View this article in WRRO
- Role of purinergic receptor polymorphisms in human bone. FRONT BIOSCI-LANDMRK, 16, 2572-2585.
- LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.. Cancer Res, 71(5), 1561-1572.
- Fast Facts: Osteoporosis, 6th edition. PERSPECT PUBLIC HEAL, 131(1), 48-48.
- The Effect of Different P2X(7) Receptor Antagonists on the Formation and Function of Human Osteoclast in vitro. PURINERG SIGNAL, 6(1), 139-140.
- The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro. Purinergic Signalling, 6(3), 307-315.
- Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections. American Journal of Pathology, 175(6), 2668-2675.
- PPAR agonists odulate human osteoclast formation and activity in vitro. BONE, 40(1), 149-159.
- In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: An improved isolation and cryopreservation method. Bone, 37(4), 530-544.
- Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.. Calcif Tissue Int, 73(4), 361-369.
- Multinucleated osteoclast formation in vivo and in vitro by P2X(7) receptor-deficient mice. CRIT REV EUKAR GENE, 13(2-4), 243-253.
- P2 receptors in bone - Modulation of osteoclast formation and activity via P2X(7) activation. CRIT REV EUKAR GENE, 13(2-4), 237-242.
- Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand.. Bone, 31(5), 582-590.
- Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.. Bone, 28(5), 507-512.
- Expression of a P2X7 receptor by a subpopulation of human osteoblasts.. J Bone Miner Res, 16(5), 846-856.
All publications
Journal articles
- Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
- Retraction Note: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature, 617(7959), 208-208.
- YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522. Journal of Bone Oncology, 39, 100474-100474.
- Editorial: New therapies in the treatment of sarcomas. Frontiers in Endocrinology, 14.
- The kinesin gene KIF26B modulates the severity of post-traumatic heterotopic ossification. International Journal of Molecular Sciences, 23(16). View this article in WRRO
- Absence of P2Y2 receptor does not prevent bone destruction in a murine model of muscle paralysis-induced bone loss. Frontiers in Endocrinology, 13. View this article in WRRO
- Defining the role of P2X4 receptor in the prostate cancer bone metastasis. Bone Reports, 16, 101209-101209.
- A systematic review of the expression, signalling and function of P2 receptors in primary bone cancer. Frontiers in Bioscience-Landmark, 27(4).
- A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell Discovery, 8(1).
- The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties. Journal of Bone Oncology, 31. View this article in WRRO
- Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses. International Journal of Molecular Sciences, 22(10). View this article in WRRO
- Oral Communications & Poster Abstracts. JBMR PLUS, 5.
- Inhibiting the P2X4 receptor suppresses prostate cancer growth in vitro and in vivo, suggesting a potential clinical target. Cells, 9(11). View this article in WRRO
- Human P2X7 receptor causes cycle arrest in RPMI-8226 myeloma cells to alter the interaction with osteoblasts and osteoclasts. Cells, 9(11).
- PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse. Scientific Reports, 10(1). View this article in WRRO
- Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification.
- Correction: LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution. Cancer Research, 79(19), 5123-5123.
- P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis. Scientific Reports, 8(1). View this article in WRRO
- Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study. Journal of Orthopaedic Research, 35(10), 2323-2328. View this article in WRRO
- Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor. Purinergic Signalling.
- Restoration of body composition and bone integrity following cryopreserved ovarian tissue auto-grafting in a rat model. Cryobiology, 73(3), 416-416.
- A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population. Frontiers in Endocrinology, 7. View this article in WRRO
- Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement.. Journal of Orthopaedic Research. View this article in WRRO
- The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. Journal of Bone Oncology. View this article in WRRO
- Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing. Frontiers in Endocrinology, 7. View this article in WRRO
- Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. Purinergic Signalling, 12(1), 103-113.
- Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis. Cancer Research, 76(2), 188-192.
- Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data in Brief, 5, 621-625. View this article in WRRO
- The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature, 522(7554), 106-110. View this article in WRRO
- Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
- P2X7 receptors: role in bone cell formation and function. Journal of Molecular Endocrinology, 54(2), R75-R88.
- Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
- Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma. PLoS ONE, 9(9). View this article in WRRO
- Editorial overview: Musculoskeletal: Are we on the road to personalised medicine in musculoskeletal diseases?. Curr Opin Pharmacol, 16, vii-ix.
- Targeting P2 receptors--current progress in treating musculoskeletal diseases.. Curr Opin Pharmacol, 16, 122-126. View this article in WRRO
- The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development.. FASEB J, 28(5), 2249-2259. View this article in WRRO
- Role of the P2Y
13 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes. Stem Cells, 31(12), 2747-2758. View this article in WRRO
- Role of the P2X7 receptor in the osteogenic differentiation of mesenchymal cells and in osteoclast fusion: Presented by: Maria P. Abbracchio. Purinergic Signalling, 9(3), 281-284. View this article in WRRO
- The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.. J Bone Miner Res, 28(6), 1446-1456. View this article in WRRO
- Generation of a novel mouse model for the inducible depletion of macrophages in vivo.. Genesis, 51(1), 41-49.
- Genetic background strongly influences the bone phenotype of P2X7 receptor knockout mice. Journal of Osteoporosis, 2012. View this article in WRRO
- The pre-metastatic niche: is metastasis random?. BoneKEy Reports, 1(5).
- Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.. Eur J Hum Genet, 20(5), 559-564. View this article in WRRO
- P2X receptors in bone. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 1(2), 221-227.
- Purinergic signalling in bone.. Front Endocrinol (Lausanne), 3, 116. View this article in WRRO
- Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics.
- Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.. Mol Endocrinol, 26(1), 142-152. View this article in WRRO
- Primary human osteoblast cultures.. Methods Mol Biol, 816, 3-18.
- Purinergic signalling in osteoblasts.. Front Biosci (Landmark Ed), 17, 16-29.
- Human osteoclast culture and phenotypic characterization.. Methods Mol Biol, 806, 357-375.
- Isolation and culture of human osteoblasts.. Methods Mol Biol, 806, 337-355.
- Application of multiple forms of mechanical loading to human osteoblasts reveals increased ATP release in response to fluid flow in 3D cultures and differential regulation of immediate early genes.. J Biomech, 45(3), 549-554.
- The P2Y(6) receptor stimulates bone resorption by osteoclasts.. Endocrinology, 152(10), 3706-3716. View this article in WRRO
- Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.. Bone, 49(4), 717-723. View this article in WRRO
- Bone phenotypes of P2 receptor knockout mice. Frontiers in Bioscience(S3), 1038-1046.
- Role of purinergic receptor polymorphisms in human bone. FRONT BIOSCI-LANDMRK, 16, 2572-2585.
- LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.. Cancer Res, 71(5), 1561-1572.
- Fast Facts: Osteoporosis, 6th edition. PERSPECT PUBLIC HEAL, 131(1), 48-48.
- 1st UK Purine Symposium. Purinergic Signalling, 6(1), 125-144.
- The Effect of Different P2X(7) Receptor Antagonists on the Formation and Function of Human Osteoclast in vitro. PURINERG SIGNAL, 6(1), 139-140.
- The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro. Purinergic Signalling, 6(3), 307-315.
- The role of the P2X←7 receptor in bone cell function..
- Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections. American Journal of Pathology, 175(6), 2668-2675.
- PPAR agonists odulate human osteoclast formation and activity in vitro. BONE, 40(1), 149-159.
- In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: An improved isolation and cryopreservation method. Bone, 37(4), 530-544.
- A New Histomorphometric Method to Assess Growth Plate Chondrodysplasia and Its Application to theToothless(tl, Csf1nullOsteopetrotic Rat. Connective Tissue Research, 45(1), 1-10.
- Expression of Vascular Endothelial Growth Factor in the Dental Follicle. Critical Reviews in Eukaryotic Gene Expression, 13(2-4), 8-8.
- Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.. Calcif Tissue Int, 73(4), 361-369.
- Perspective osteoclastogenesis and growth plate chondrocyte differentiation: Emergence of convergence. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 13(2-4), 181-193.
- Expression of vascular endothelial growth factor in the dental follicle.. Crit Rev Eukaryot Gene Expr, 13(2-4), 173-180.
- Multinucleated osteoclast formation in vivo and in vitro by P2X(7) receptor-deficient mice. CRIT REV EUKAR GENE, 13(2-4), 243-253.
- P2 receptors in bone - Modulation of osteoclast formation and activity via P2X(7) activation. CRIT REV EUKAR GENE, 13(2-4), 237-242.
- Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand.. Bone, 31(5), 582-590.
- Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.. Bone, 28(5), 507-512.
- Expression of a P2X7 receptor by a subpopulation of human osteoblasts.. J Bone Miner Res, 16(5), 846-856.
- EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report. Purinergic Signalling.
- C‐terminal variants of the P2X7 receptor are associated with prostate cancer progression and bone metastasis – evidence from clinical and pre‐clinical data. Cancer Communications.
- The strategy and clinical relevance of in vitro models of MAP resistance in osteosarcoma: a systematic review. Oncogene.
- RSPO2/RANKL-LGR4 signaling regulates osteoclastic pre-metastatic niche formation and bone metastasis. Journal of Clinical Investigation.
- Purinergic ADP receptors: from block buster blood drugs to bone-disease busters. IBMS BoneKEy, 10.
Chapters
- Osteosarcoma, Encyclopedia of Bone Biology (pp. 362-378). Elsevier
- The role of purinergic signaling in the interactions between skeletal cells, Nucleotides and Regulation of Bone Cell Function (pp. 61-74).
- Isolation and culture of human osteoblasts. (pp. 29-54).
Conference proceedings papers
- Abstract 2904: Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone. Cancer Research, Vol. 81(13_Supplement) (pp 2904-2904)
- Primordial signalling in prehistoric cancer. JOURNAL OF ANATOMY, Vol. 238(1) (pp 191-191)
- Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13)
- Longitudinal Effects of Combined Bone Anabolic Interventions on Ovariectomised Mice. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 258-259)
- P2X7R in primary bone cancer. PURINERGIC SIGNALLING, Vol. 14 (pp S13-S14)
- The P2X7 Antagonist AFC-5261 rescues Ovariectomy-induced Bone Loss in Mice.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S402-S403)
- A Novel Factor Derived From Resorbing Bone In Vitro Potently Stimulates C-Fos Expression In Breast Cancer Cells. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- P2X7 Receptor Polymorphisms Modulate Osteoblast Cell Functions. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- TIBIAL PLATEAU BONE SURFACE ROUGHNESS - A POTENTIAL NEW EARLY MARKER TO DETECT ARTHRITIS?. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S574-S574)
- SPECIATION AND DISTRIBUTION OF COBALT AND CHROMIUM IN OSTEOBLASTS AND OSTEOCLASTS USING MICROFOCUS X-RAY FLUORESCENCE AND X-RAY ABSORPTION NEAR-EDGE STRUCTURE. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S592-S592)
- P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S85-S86)
- P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S67-S67)
- Association of polymorphisms in the P2X7 receptor gene with stress fracture risk in military recruits. BONE, Vol. 50 (pp S108-S108)
- Expression of NFATc1 is inducible by P2X7 receptor activation in human osteoclasts. BONE, Vol. 48 (pp S126-S126)
- Deletion of the P2Y13 receptor leads to reduced bone turnover and protection from ovariectomy-induced bone loss. BONE, Vol. 48 (pp S227-S227)
- Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation. BONE, Vol. 48(1) (pp S21-S21)
- Bone status of P2X7 knockout mice in two different strains. PURINERG SIGNAL, Vol. 6 (pp 158-158)
- The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERG SIGNAL, Vol. 6(1) (pp 140-140)
- Bone Phenotype of P2Y13 Receptor Knock-Out Mice. PURINERG SIGNAL, Vol. 6(1) (pp 144-144)
- The role of P2X(7) receptors in ATP release from osteoblasts. PURINERG SIGNAL, Vol. 6(1) (pp 129-129)
- The effect of cobalt and chromium ions at clinically relevant concentrations on human osteoblast and osteoclast physiology in vitro: implications for skeletal health. BONE, Vol. 46 (pp S71-S71)
- Regulation of osteoblast function and mineralisation by extracellular nucleotides: The role of P2Y and P2X receptors. BONE, Vol. 44 (pp S154-S154)
- Loss of Function Polymorphisms in The P2X(7) Receptor Gene Are Associated with Accelerated Lumbar Spine Bone Loss in Postmenopausal Women.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S296-S296)
- A Novel Selective P2X(7) Receptor Antagonist Inhibits Human Osteoclast Formation in vitro.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S403-S403)
- Microct analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. CALCIFIED TISSUE INT, Vol. 83(1) (pp 2-3)
- ATP release from osteoblasts is increased in response to mechanical loading by different amounts when grown in standard monolayer and novel 3D scaffolds. CALCIFIED TISSUE INT, Vol. 83(1) (pp 16-16)
- The effect of ATP, alone and in combination with EGF, on breast cancer cell survival. PURINERG SIGNAL, Vol. 4 (pp S205-S206)
- A polymorphism in the P2X7 receptor gene is associated with loss of lumbar spine bone mineral density in postmenopausal women. PURINERG SIGNAL, Vol. 4 (pp S172-S173)
- MicroCT analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. PURINERG SIGNAL, Vol. 4 (pp S176-S176)
- Regulation and mechanisms of ATP release from osteoblasts. PURINERG SIGNAL, Vol. 4 (pp S161-S161)
- Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165)
- Cyclical compressive loading induces changes in cellular behaviour and ATP release from osteoblasts grown on 3-dimensional scaffolds. CALCIFIED TISSUE INT, Vol. 82 (pp S115-S116)
- Novel association between a polymorphism in the P2X7 receptor gene and loss of lumbar spine bone mineral density in postmenopausal women. CALCIFIED TISSUE INT, Vol. 82 (pp S43-S43)
- ATP is released from human osteoblasts by multiple mechanisms.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22 (pp S146-S146)
- Release of ATP from human osteoblastic cell lines and primary osteoblasts occurs via exocytosis. BONE, Vol. 38(3) (pp S11-S11)
- The synergistic effect of extracellular nucleotides and EGF on c-fos expression in two breast cancer cell lines. BONE, Vol. 38(3) (pp S35-S35)
- Low dose PTH, insufficient to induce cyclic AMP or C-fos, stimulates an anabolic gene response in human osteoblasts in vitro. BONE, Vol. 38(3) (pp S10-S11)
- Regulation of ATP release from human osteoblasts: A calcium dependant, exocytotic vesicular mechanism. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S49-S49)
- Differential effect of PPAR agonists on human recombinant RANKL generated osteoclast culture in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1303-1303)
- A biphasic pattern of osteoblast gene expression by differing concentrations of PTH 1-34. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1308-1308)
- ATP release and P2 receptor expression by human chondrocytes.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1301-1301)
- Effect of PPAR agonists, on human osteoclast formation and activity in vitro. BONE, Vol. 36 (pp S300-S301)
- Cellular and molecular characterization of primary rat chondrocytes differentiated in culture. BONE, Vol. 36 (pp S173-S173)
- The effects of extracellular nucleotides on EGF-induced c-fos gene expression. BONE, Vol. 36 (pp S256-S256)
- Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S32-S32)
- Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S255-S255)
- Abnormal septoclasts at the chondroosseous junction in the TL rat are normalised following CSF-1 treatment. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1049-1049)
- Osteopetrotic chondrodysplasia in the toothless (CSF-1null) rat: A paradigm for the role of osteoclastogenic factors as integrators of endochondral ossification. BONE, Vol. 34 (pp S38-S38)
- CSF-1 treatment corrects septoclast abnormalities at the chondroosseous junction in the Toothless rat.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S111-S111)
- Chondrocytes from the osteopetrotic mutation toothless (TL)/Csf-1 null rat differentiate in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1370-1370)
- Chondrocytes, growth plates, and RANKL-induced signalling: Observations and implications of osteopetrotic mutations. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1339-1339)
- P2X(7) receptor-deficient mice maintain the ability to form multinucleated) osteoclasts in vivo and in vitro. J BONE MINER RES, Vol. 17(7) (pp 1338-1338)
- Blockade of P2X(7) receptors inhibits osteoclast fusion in vitro. BONE, Vol. 28(5) (pp S166-S167)
- ATP released into the extracellular environment by osteoblasts regulates differentiation and apoptosis of bone cells.. J BONE MINER RES, Vol. 15 (pp S476-S476)
- Expression of the pore forming P2X(7) receptor by human rank ligand-generated osteoclasts and human osteoclastic cells in situ.. J BONE MINER RES, Vol. 15(6) (pp 1227-1227)
- The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. Purinergic Signalling, Vol. 6(1) (pp 140). Sheffield
Preprints
- The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis, Cold Spring Harbor Laboratory.
- Combining PTH(1-34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice, Research Square Platform LLC.
- P2RX7 inhibition reduces breast cancer induced osteolytic lesions - implications for bone metastasis, Cold Spring Harbor Laboratory.
- The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties.
- The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. Journal of Bone Oncology. View this article in WRRO
- Research group
-
Current Collaborators
- Professor Mark Wilkinson
- Dr Dawn Teare
- Dr Gaynor Miller
- Dr Shelly Lawson
Postgraduate Students
- Mr Luke Tattersall
- Teaching interests
-
I am Chair of the Medical School Graduate Research Committee, I lecture on the undergraduate Medical Course as well as being the academic lead for the research Attachment SSC, I also run the Doctoral Development Programme module "Effective Presentation and Seminar Participation" MED605.
- Professional activities and memberships
-
I am the Founder and President of the UK Purine Club, and member of the Bone Research Society, European Calcified Tissue Society, the International Bone and Mineral Society and the American Society for Bone and Mineral Research.